Antibiotic resistance mechanisms are the diverse strategies used by bacteria to survive the effects of antibiotics. These include enzymatic degradation of the drug, alteration of target sites, changes in membrane permeability, and active efflux of the antibiotic. Such mechanisms make it difficult to treat common infections and are a major public health concern. Overuse and misuse of antibiotics in humans and animals contribute to this growing threat. Understanding antibiotic resistance mechanisms is vital for developing new treatments and preserving the effectiveness of existing antibiotics. Scientists and healthcare professionals must work together to combat this challenge effectively.